Are you passionate about drug development and curious about how molecules can fight diseases? Do you want to contribute to breakthrough technologies that modulate protein-protein interactions in cells? If so, join the Department of Synthetic Organic Chemistry as a PhD candidate!

We aim to develop new drug development technology based on the design and synthesis of a unique class of molecules to modulate the so-called protein-protein interactions in the cell. Protein-protein interactions are very common in metabolic pathways and their malfunctioning leads to diseases. Using computer modelling, and by synthesising unique compound libraries and screening for biological activity, new druglike molecules will be developed that may form the basis for future drugs.

As a PhD candidate on this multidisciplinary project, your main task will be to develop new and efficient synthesis routes to novel classes of small molecules that can interfere with protein-protein interactions. You will closely collaborate with other project partners on several aspects of early-stage drug discovery, including molecular modelling, scale-up of strategic building blocks, automated library synthesis, assay development and screening for biological activity.

In addition to conducting research, your PhD position will include other training activities, such as participation in teaching (10%). This involves assisting with lab courses, as well as supervising and training Bachelor's and Master's students as part of your own research project

Qualifications

1. You have an MSc degree in chemistry or in a related molecular science programme. You have excellent knowledge of organic reactions and extensive experience with the design and synthesis of small molecules.
2. You have preferably used your synthesis skills in medicinal chemistry projects. You are enthusiastic about conducting research and capable of overseeing complex multidisciplinary problems. You have excellent communicative skills and are a team player.