• Description:

    A controlled permeabilization of cells to facilitate cytosolic delivery of synthetic peptides and other biomolecules would greatly benefit the development of novel therapeutics but also poses a major challenge to medicinal chemistry. Various synthetic carriers that affect non-lytic membrane passage of bioactive cargos have been reported. However, insights into how these carriers disrupt the membrane barrier and how cells respond to this breach in structural integrity have remained elusive owing to a lack of experimental approaches enabling selective interrogation. The successful candidate will join the DFG-funded Research Training Group RTG-2900 “nanomaterials@biomembranes” to investigate novel supramolecular materials for their capacity to promote plasma membrane passage of peptide cargo and trigger membrane damage response pathways. Toward this end, surface architectures of membrane bilayer-destabilizing supramolecular materials will be combined with super-resolution live cell imaging technologies to interrogate cargo transport and membrane repair-associated lipid scrambling at confined sites of cell permeabilization. Besides contributing to the development of novel strategies for the cytosolic delivery of polar therapeutics, the project should also help elucidate how cells exploit Ca2+-activated lipid scramblases to detect and clear minor lesions in their membranes.

    Qualifications 

    • Completed degree (M.Sc.) in biology, (bio)chemistry or biophysics
    • Solid background in assay development ideally combined with expertise in live cell microscopy
    • Strong interest in interdisciplinary research
    • Ability to work in a team and willingness to engage in multilateral research cooperation
    • Very good command of written and spoken English

     

     

  • Fields

    • Biochemistry

    • Biology

  • Qualifications

    • Master

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