• Description:

    This PhD project delves into the intricate relationship between the microbiome and two critical health conditions: Inflammatory Bowel Disease (IBD) and its associated risk factor, Colorectal Cancer (CRC). Led by a team of esteemed researchers including Dr. Johan Vande Voorde, Dr. Kevin Myant, Prof. Konstantinos Gerasimidis, Dr. Shahida Din, and Prof. Owen Sansom, this project aims to unravel how dysbiosis within the gut microbiota contributes to the progression of IBD and its link to CRC. By employing advanced methodologies, the project seeks to identify microbial alterations and metabolite changes that drive disease severity, paving the way for innovative intervention strategies.

    Inflammatory Bowel Disease (IBD) poses a significant risk factor for Colorectal Cancer (CRC), with dysbiosis in the gut microbiota playing a pivotal role in disease progression. This project, led by a collaborative team of experts, aims to dissect the complex interplay between microbial alterations, metabolite abundance, and disease severity in IBD-CRC. Through a combination of cutting-edge techniques including longitudinal metabolomics analysis, 16S amplicon sequencing, and in vivo studies utilizing genetically engineered mouse models, the project endeavors to uncover novel insights into disease mechanisms. By understanding the molecular underpinnings of IBD-CRC, the project aims to develop targeted intervention strategies to improve patient outcomes.

    Eligibility 

    Prospective candidates should hold a PhD in a relevant field and preferably possess experience in preclinical models, metabolomics, and molecular biology.

  • Fields

    • Biological Sciences

    • Biology

  • Qualifications

    • PhD

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