The Zampieri Lab at the Department of Biomedicine, a joint effort between the University of Basel and the University Hospitals Basel, is offering a PhD position in computational biology. The position is part of the MERKUR-funded project in systems pharmacology, computational biology, and metabolic regulation. The successful candidate will contribute to groundbreaking research in collaboration with Prof. Sarah Tschudin Sutter at the University Hospital of Basel and Prof. Urs Jenal at the Biozentrum.
The selected candidate will be involved in the NCCR AntiResist project and will work on uncovering the role of central metabolism in mediating antibiotic tolerance. Key responsibilities include:
- Developing new strategies to combine high-throughput metabolomics with single-cell analysis of metabolic and transcriptional reporters.
- Investigating variations in metabolic activity as metabolic mediators of antibiotic tolerance.
- Determining mechanisms linking regulation of respiro-/fermentative metabolism to phenotypic heterogeneity and antibiotic tolerance.
- Testing the relevance of metabolic tolerance in clinical strains.
- Supporting and preparing scientific reports and journal articles.
- Master’s degree in (Bio)Physics, (Bio)engineering, Biological Sciences, Microbiology, Biochemistry, Systems Biology, Molecular Biology, Bioinformatics/Computational Biology, or related fields.
- Basic experience in designing and running experiments with microbial cultures in the laboratory.
- Hands-on experience with key biochemical and molecular biological methods.
- Motivation to work in an international research environment.
- Experience with and/or motivation to learn systems biology approaches, high-throughput methodologies, and analysis of single-cell imaging data.
- Experience with and motivation to learn programming languages (e.g., Matlab, R, or Python).
- Good communication skills.
- Cover letter
- Complete curriculum vitae
- PhD application form
- References from at least two referees.